English
norskBlar i forfatter "Johnsen, Erik"
Viser treff 1-10 av 10
-
Does childhood trauma influence cognitive functioning in schizophrenia? The association of childhood trauma and cognition in schizophrenia spectrum disorders.
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-05-19)Childhood trauma (CT) is a risk factor for schizophrenia spectrum disorders (SSDs), and cognitive impairment is a core feature and a vulnerability marker of SSDs. Studies of the relationship between CT and cognitive impairment in SSDs are inconclusive. In addition, few studies have examined differential effects of CT subtypes, e.g. physical, sexual or emotional abuse/neglect, on cognitive functioning. ... -
Impact of childhood trauma on antipsychotic effectiveness in schizophrenia spectrum disorders: A prospective, pragmatic, semi-randomized trial
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-13)Antipsychotic medications are generally effective in ameliorating psychotic symptoms in schizophrenia spectrum disorders (SSDs). Identifying predictors associated with poor treatment response is important for a personalized treatment approach. Childhood trauma (CT) may have a general and differential effect on the effectiveness of different types of antipsychotics in SSDs. The Bergen-Stavanger- ... -
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-07)Background -Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI are not known yet. Recently, dyslipidemia has been linked to systemic inflammasome activation, and elevated atherogenic ... -
Increased circulating IL-18 levels in severe mental disorders indicate systemic inflammasome activation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-07)Background - Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental illnesses (SMI) that are part of a psychosis continuum, and dysregulated innate immune responses have been suggested to be involved in their pathophysiology. However, disease-specific immune mechanisms in SMI are not known yet. Recently, dyslipidemia has been linked to systemic inflammasome activation, and elevated atherogenic ... -
Lower circulating neuron-specific enolase concentrations in adults and adolescents with severe mental illness
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-11)Background - Both neurodegenerative and neurodevelopmental abnormalities have been suggested to be part of the etiopathology of severe mental illness (SMI). Neuron-specific enolase (NSE), mainly located in the neuronal cytoplasm, may indicate the process as it is upregulated after neuronal injury while a switch from non-neuronal enolase to NSE occurs during neuronal maturation.<p> <p>Methods - ... -
Pilot-RCT Finds No Evidence for Modulation of Neuronal Networks of Auditory Hallucinations by Transcranial Direct Current Stimulation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-12)Background: Transcranial direct current stimulation (tDCS) is used as treatment for auditory verbal hallucinations (AVH). The theory behind the treatment is that tDCS increases activity in prefrontal cognitive control areas, which are assumed to be hypoactive, and simultaneously decreases activity in temporal speech perception areas, which are assumed to be hyperactive during AVH. We tested this ... -
Quality of clinical management of cardiometabolic risk factors in patients with severe mental illness in a specialist mental health care setting
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-24)Purpose: Cardiometabolic disease in patients with severe mental illness is a major cause of shortened life expectancy. There is sparse evidence of real-world clinical risk prevention practice. We investigated levels of assessments of cardiometabolic risk factors and risk management interventions in patients with severe mental illness in the Norwegian mental health service according to an acknowledged ... -
Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-02)<p><b>Background</b> Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI), by promoting inflammatory and immune-mediated responses and mediating signals across blood-brain barrier. We hypothesized that CAMs would be dysregulated in SMI and evaluated plasma levels of different vascular and ... -
Tromsø kommune Eiendom : en lærende organisasjon?
(Master thesis; Mastergradsoppgave, 2007-11-15)Tema i oppgaven kan plasseres innenfor organisasjonsteorien, nærmere bestemt innenfor læring i organisasjoner og den lærende organisasjonen. Jeg skal se om mål TKE hadde før samlokaliseringen har blitt oppnådd innenfor disse områdene. Videre vil jeg se på om, eller i hvilken grad TKE er en lærende organisasjon. Foregår det noe som helst læring på organisasjonsnivået, eller skjer dette bare på ... -
Turnover of IPS employment specialists: Rates and predictors
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-15)BACKGROUND: There are anecdotal reports of high job turnover of Individual Placement and Support employment specialists. However, no studies have addressed this issue.<p> <p>OBJECTIVE: To explore whether turnover rates among employment specialists are higher compared to public sector employees along with the correlates of turnover intentions. <p>METHODS: A repeated cross-sectional study collected ...
